Midterm 1 Problems - 2008 - UC Berkeley, Chem C130/MCB...

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UC Berkeley, Chem C130/MCB 100A, Fall 2008, Mid-term Exam 1. Your Name___________________________ Page 1 of 14 UNIVERSITY OF CALIFORNIA, BERKELEY CHEM C130/MCB C100A MIDTERM EXAMINATION #1 SEPTEMBER 25, 2008 INSTRUCTORS: John Kuriyan and Bryan Krantz THE TIME LIMIT FOR THIS EXAMINATION: 1 HOUR 20 MINUTES SIGNATURE: ________________________________________________________________ Please SIGN your name on the line above in INDELIBLE INK . YOUR NAME: ________________________________________________________________ PLEASE PRINT your name ( IN INDELIBLE INK ) on the line above (& on the top right hand corner of every page). PLEASE CIRCLE the name of your GSI: Jonas Lee Mark Walker Katie Thoren Kate Engel PLEASE WRITE all of your answers AS LEGIBLY AS POSSIBLE . SCORING. The exam consists of 4 questions worth 25 pts each totaling 100 pts as broken down in this table: Question Part A Part B Part C Part D Your Total Maximum Score 1. (10) (10) (5) --------------- 25 2. (6) (7) (6) (6) 25 3. (8) (10) (7) --------------- 25 4. (3) (22) -------------- - --------------- 25 TOTAL b 100
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UC Berkeley, Chem C130/MCB 100A, Fall 2008, Mid-term Exam 1. Your Name___________________________ Page 2 of 14 QUESTION 1 (25 PTS TOTAL) Q1. Part A (10 points) The diagram above shows three different base pairs, involving A, T, C, G or U. (i) (4 points) Identify each of the nucleotides, using the single letter code. A ____________ B ____________ C ____________ D ____________ (ii) (2 points) One of the base pairs is a standard Watson-Crick basepair, and one is not. Which is the non-standard basepair? (iii) (2 points) Fill in the chemical groups that are missing in the 4 empty boxes. (iv) (2 points) For each basepair, indicate the hydrogen bonds with a dashed line. For each hydrogen bond, fill in any missing hydrogen atoms.
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UC Berkeley, Chem C130/MCB 100A, Fall 2008, Mid-term Exam 1. Your Name___________________________ Page 3 of 14 Q1. Part B (10 points) C N H N C C N H O H C O O O H CH 3 . . . H . . A B Base C Base D In the diagram above, two amino acid sidechains are shown interacting with a Watson- Crick basepair, which is part of a double helical structure. (i) (4 points) What are the amino acids labeled A and B? Give the three letter and single letter codes. A = B = (ii) (2 points) What are the nucleotides labeled C and D? Give the single letter codes. C = D = (iii) (4 points) Is this interaction occurring in the major or minor groove? Explain your reasoning.
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UC Berkeley, Chem C130/MCB 100A, Fall 2008, Mid-term Exam 1. Your Name___________________________ Page 4 of 14 Q1. PART C (5 POINTS) Consider the RNA sequence: 5'-AACUAGUGCGCAAGCACUGGUU-3' Select the most likely secondary structure diagram for this sequence from the 4 choices shown below. In the drawing, the sugar-phosphate backbone is indicated as a solid line and the bases are shown as boxes. (i)
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This note was uploaded on 02/23/2011 for the course MCB 100A taught by Professor Kuryian during the Spring '09 term at University of California, Berkeley.

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Midterm 1 Problems - 2008 - UC Berkeley, Chem C130/MCB...

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