Midterm 1 Problems - 2009 - John Kuriyan- 1 - UNIVERSITY OF...

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Unformatted text preview: John Kuriyan- 1 - UNIVERSITY OF CALIFORNIA, BERKELEY CHEM C130/MCB C100A MIDTERM EXAMINATION #1 SEPTEMBER 24, 2009 INSTRUCTORS: John Kuriyan and David Wemmer THE TIME LIMIT FOR THIS EXAMINATION: 1 HOUR 20 MINUTES SIGNATURE: ________________________________________________________________ Please SIGN your name on the line above in INDELIBLE INK . YOUR NAME: ________________________________________________________________ PLEASE PRINT your name ( IN INDELIBLE INK ) on the line above (& on the top right hand corner of every page). PLEASE CIRCLE the name of your GSI: Anna Asmundson Geo f rey Feld Zhijuan Gao Patrick Visperas PLEASE WRITE all of your answers AS LEGIBLY AS POSSIBLE . SCORING. The exam consists of 4 questions. Questions 1 and 2 are worth 25 points each, Question 3 is worth 26 points and Question 4 is worth 24 points, totaling 100 points as broken down in this table: Question Part A Part B Part C Part D Your Total Maximum Score 1. [4] [11] [10]--------------- 25 2. [12] [4] [3] [7] 26 3. [10] [6] [5] [4] 25 4. [24]-------------- ------------------------------ 24 TOTAL ! 100 UC Berkeley, Chem C130/MCB 100A, Fall 2009, Mid-term Exam 1. Your Name___________________________ Page 1 of 12 John Kuriyan- 2 - Q1 (25 points total) Q1A. (4 points) During DNA replication, the growing strands is extended in only the 5 to 3 direction. Why is the extension of the strand restricted to just one direction? Explain your answer fully. Q1B. (11 points) The Fgure below is a small region of the structure of an RNA riboswitch that recognizes a nucleic acid base. The base being recognized is at the center. Hydrogen atoms are not shown. (i) (1 point) Identify the base being recognized. Write the name of the base on the blank line provided. (ii) (4 points) Label all of the N and O atoms of the base. (iii) (6 points) Three hydrogen bonds made by the base are shown by dotted lines. or each hydrogen bond, label the N and O atoms on the RNA riboswitch. Draw a covalent bond between the appropriate N or O atom and the hydrogen atom involved in the hydrogen bond. UC Berkeley, Chem C130/MCB 100A, Fall 2009, Mid-term Exam 1. Your Name___________________________ Page 2 of 12 (name = ______________) John Kuriyan- 2 - Q1 (25 points total) Q1A. (4 points) During DNA replication, the growing strands is extended in only the 5 to 3 direction. Why is the extension of the strand restricted to just one direction? Explain your answer fully. Q1B. (11 points) The Fgure below is a small region of the structure of an RNA riboswitch that recognizes a nucleic acid base. The base being recognized is at the center. Hydrogen atoms are not shown. (i) (1 point) Identify the base being recognized. Write the name of the base on the blank line provided....
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This note was uploaded on 02/23/2011 for the course MCB 100A taught by Professor Kuryian during the Spring '09 term at University of California, Berkeley.

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Midterm 1 Problems - 2009 - John Kuriyan- 1 - UNIVERSITY OF...

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