22 - 22.4 http/faculty.plattsburgh.edu/donald.slish/Telomerase.html Replication of the ends of linear chromosomes 22.5 Telomerase(RNA-protein The

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Telomeres Eukaryotic chromosomes are linear, not circular Telomers - structures at the ends of linear chromosomes Ends of chromosomes Highly conserved telomere structures at the ends of linear chromosomes tandem repeat DNA sequences (GT-rich repeats with a single- stranded 3 overhang) and associated proteins. Variety of functions retaining genome integrity and stability and in regulating cell lifespan. http://www.metasystems.de/products/isis/isis _telomere.htm gladstone.uoregon.edu/~gwang/Aging.ppt
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Unformatted text preview: 22.4 http://faculty.plattsburgh.edu/donald.slish/Telomerase.html Replication of the ends of linear chromosomes 22.5 Telomerase (RNA-protein): The RNA subunit is held into the complex by interactions with the N-terminal domain of TERT (the protein reverse transcriptase). This leaves the template (CA-containing sequence) free to move through the RT domain so that a single active site (triangle) can catalyze nucleotide addition at multiple positions. Telomerase RNA 22.6 The telomerase reaction 22.7 22.8...
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This note was uploaded on 02/23/2011 for the course CHEM 4731 taught by Professor Mchenry during the Spring '08 term at Colorado.

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22 - 22.4 http/faculty.plattsburgh.edu/donald.slish/Telomerase.html Replication of the ends of linear chromosomes 22.5 Telomerase(RNA-protein The

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