HW2 - CHEM 4731/5731 Name_KEY Problem Set#2 Cholesterol...

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CHEM 4731/5731 Name: _KEY_____________________ Problem Set #2: Cholesterol metabolism, ketone bodies, lipid biosynthesis Due in class Tu e sday, February 1 , 2011 1. The mechanism for the reaction catalyzed by HMG-CoA Reductase consists of only two steps, both of which use NADPH as a reducing agent. Draw a likely two-step mechanism for this reaction. Use arrows to indicate movement of electrons. Show structures of all portions of substrates, cofactors, intermediates, and products important to the reaction mechanism. Other portions of these molecules can be abbreviated. (Hint: coenzyme A is released in the second step).
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2 . Write a properly balanced chemical equation for the oxidation of stearic acid (chemical formula CH 3 (CH 2 ) 16 COOH) to CO 2 . Take all NADH and FADH 2 through electron transport and oxidative phosphorylation. Show your work below. Do not assume that GTP=ATP in answering this question. AMP should not be found in the final balanced equation.
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3a. How many ATP equivalents (assuming GTP=ATP) are produced by the complete oxidation of acetoacetate to CO(2) and water?
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