iphy 3430 2-3-11

iphy 3430 2-3-11 - 2/1/11 IPHY 3430 9-23-10 ULCERS...

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2/1/11 1 IPHY 3430 9-23-10 ULCERS Protection against stomach acid 1. Mucosal barrier 2. Membranes of mucosal cells impermeable to acid 3. Tight junctions between cells 4. Rapid turnover of cells Ulcers, cont. Causes: 1. Helicobacter pylori a. secretes urease b. Fagellae help them tunnel into stomach wall c. avoid acid producing areas of stomach 2. Alcohol, non- steroidal, anti-inFammatory drugs (aspirin, etc) 3. Stress induces overproduction of HCl
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2/1/11 2 Vomiting stimuli--> Vomiting center in medulla --> motor output --> PNS and SNS output Vomiting, cont. Stimuli: a. toxins in stomach b. pressure receptors at back of throat, tongue c. elevated intracranial pressure d. dizziness e. emotional stress (Psychogenic) Vomiting, cont. Motor output: 1. contraction of inspiratory muscles (esp. diaphragm) 2. glottis and epiglottis closure 3. abdominal muscles contract 4. uvula elevated to close off nasal passages 5. Jaw thrusts out, opening pharyngoesophageal sphincter PNS output: Salivation, nausea SNS output: sweating, increased heart rate
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iphy 3430 2-3-11 - 2/1/11 IPHY 3430 9-23-10 ULCERS...

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