Homework3(AnswerKey) - ∆ H – negative so that ∆ G is...

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Name Chem 4711, Homework 3 (Due 10/11 in class) Only use the space provided to answer the following questions. 1. In the following molecule, which protons are acidic enough for an enzyme to pull them off? 2. Why is the proximal histidine critical in hemoglobin? Depending upon how you defined proximal, you could say that it results in cooperativity, or that it is important for O 2 binding and excluding CO. 3. Some water molecules bound to proteins can be observed by X-ray crystallography. Why can they be observed in terms of G, H, and S? G – must be negative, or it wouldn’t be bound. S – negative, since it has lost mobility compared to bulk water.
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Unformatted text preview: ∆ H – negative so that ∆ G is negative 4. Suppose that hemoglobin was an octamer ( α 4 β 4 ). What is the maximal Hill coefficient that one could obtain? 8 5. Why is protein disulfide isomerase important? Is it more important to proteins that are exported from a cell or those found in the cytosol, and why? Isomerizes disulfide bonds to allow the correct pairs to form. In exported proteins because the cytosol is a reducing environment but the extracellular milieu is oxidizing. C H 2 C C H 2 O HO H 2 C C O H 2 C C H 2 O P O OH OH...
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