DEV_2_5bb - close What consequences might that cause Spina...

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2/5/10 Neural development
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What is the biphasic effect of ethanol? Stimulant, depressant Which inhibitory NT does alcohol interact with? GABA, GABAa receptor What are the two types of tolerance? Functional , Physiological Key areas involved in the positive reward model of addiction? VTA, NAC Review
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Six overlapping stages Neurogenesis Migration Differentiation Synaptogenesis Programmed cell death Synaptic rearrangement Neuronal development
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What do these all have in common? Fetal alcohol syndrome Autism Down syndrome Rett’s disorder ADHD Anencephaly Spina bifida Hydrocepalus
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Early Development Conception Zygote Blastula Gastrula (1 week) Endoderm Liver, Pancreas, inner lining of digestive tract Mesoderm Muscles, circulatory system Ectoderm BRAIN, skin, retina
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Neurulation
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Neurulation
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Warning Graphic material ahead What Happens if the Neural Tube fails to
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Unformatted text preview: close? What consequences might that cause? Spina Bifida Anencephaly Encephalocele Neuronal development 6-8 overlapping phases Proliferation Migration Aggregation Differentiation Synaptogenesis Programmed cell death Synaptic rearrangement It’s your Birthday! Proliferation (neurogenesis, gliogenesis) Closure of Neural tube 24 days Largely complete by 20 weeks Ventricular Zone Lining cerebral ventricles Mitosis Birth Day Specific chronology It’s as easy as 1,2,3…. .7,8 …. 65. .98 Migration Inside – Out pattern Inner layers 1 st Radial glia Scaffold Radially Tangentially Mixed HOW? Immunoglubulins chemokines CAM – cell adhesion molecule...
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DEV_2_5bb - close What consequences might that cause Spina...

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