neuraldev2_8_10bb

neuraldev2_8_10bb - Well how does the axon know how to find...

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2/8/10 Neural development
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Development So Far 1. Closure of the neural tube occurs when? 24-28 days post conception 2. Neuorgenesis begins approximately on what day? 28 days post conception 3. All of the neural progenitor cells are located where? Ventricular zone 4. In this context the importance of the ectoderm is what? Cell layer that gives rise to the nervous system 5. Neuronal migration follows a ______ ______ pattern Inside out
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Aggregation Nuclei CAM’s Differentiation Identity Plastic Stem Cells It’s as easy as 1,2,3…. .7,8 …. 65. .98
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Internal Cell Autonomus Gene expression C. Elegans 302 neural cells Hard wired Induction Peer pressure Location, location location Sonic Hedgehog (shh) Flexible Differentiation
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Weiss (1924) Neurons innervate at random WRONG Axons have specific targets!
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Unformatted text preview: Well how does the axon know how to find the right target? Axonal guidance counselors! Synaptogenesis It’s as easy as 1,2,3…. .7,8 …. 65. .98 Pioneers Attractive and repellant forces Chemoattraction Netrins chemorepulsion Semaphorins Slit Neurotrophins NCAM SHH Axonal guidance Survival of the Fittest! 2 million/second Match Game Neurotrophins NGF Activity NT’s co released with neurotrophins Neural Darwinism Neural Darwinism Suicide/PCD/Apoptosis Diablo IAPs Caspases BCL-2 What triggers this reaction? Why does the brain need to undergo apoptosis? What triggers this reaction? Why does the brain need to undergo apoptosis? The story so far....
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This note was uploaded on 02/24/2011 for the course PSYC 460 taught by Professor Lawrence during the Spring '10 term at South Carolina.

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neuraldev2_8_10bb - Well how does the axon know how to find...

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