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NT'shors2_3_2010bb - NTs Addiction and Hormones Stimulants...

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NT’s, Addiction and Hormones 2/3/10
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Stimulants Methamphetamine
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Meth Methampehetamine Alertness, Euphoria, sustained effort, no rest causes release of newly synthesized monoamines (primarily DA >5-HT) Prevents reuptake, increasing synaptic presence and prolonging action Inhibits receptors that inhibit dopamine release
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D A METH : Promotes DA release Inhibits DA metabolism Reverses DAT function METH-evoked DA release DA DA DA DA DA DA DA DA DA DA DA DA DA DA DA DA DA Receptors DA DA DA DA DA DA DA DA DA DA DA DA DA DA DA DA DA VTA N Acc METH Monoamine Oxidase (MAO)
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Other stimulants Nicotine Nicotinic acetylcholine receptor (nAch) Increase Da release in VTA Cognitive enhancer? Caffeine Adenosine antagonist Prevents sleep, induces alertness
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Opiates
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Opiates Morphine, Heroin Lipid soluble Effective pain relievers Endorphins = endogenous morphines Relaxing, decreased attention, sensitivity to pain Inhibits release of GABA Highly addictive
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Alcohol
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