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thesynapse1_29_2010bb

thesynapse1_29_2010bb - • Lipid/Fat Soluble – Remains...

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NT’s and drug action at the synapse
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Review What is the most common type of synapse? Axo-dendritic NT release at the synapse is dependent on ? Ca2+ NT’s are released by the ___synaptic and binds to ______ on the ____synaptic cell. Pre, receptors, and post
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Review: Synaptic events 1. Action potential invades terminal 2. Ca2+ floods the terminal 3. Neurotransmitters (NTs),i.e. chemical messengers, are released . 4. NTs diffuse across synaptic cleft. 5. NTs bind receptors 6. NTs disengage from receptors
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QUIZ #1
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ACH Learning Arousal
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NE Mood Arousal Sex
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5HT Mood Anxiety Sex Sleep
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The synapse on drugs Psychoactives Similar to endogenous chemicals Why ? Similar NTs among different species NTs also found in plants Widely varying effects
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THC Lipid/Fat Soluble
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Unformatted text preview: • Lipid/Fat Soluble – Remains in the body for weeks. • Long lasting behavioral effects – Euphoria – Altered space time – Disorientation – Fatigue – Appetite stimulation THC • Binds to Cannabinoid receptors – CB1 • Nervous system – CB2 • Immune system • Endogenous ligands – 2-AG – Anandimide AP Glu CB1 2-AG Anandimide Negative feedback • Auto receptors – Receptors located on presynaptic terminal – bind released NT & slows release • Postsynaptic signals – NO – 2 AG – Anandamide Stimulants • Temporarily increase alertness and attention • Cocaine • Amphetamine – Adderall • Dose and time course DA Distribution Stimulants • Methamphetamine...
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