thesynapse1_29_2010bb

thesynapse1_29_2010bb - Lipid/Fat Soluble Remains in the...

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NT’s and drug action at the synapse
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Review What is the most common type of synapse? Axo-dendritic NT release at the synapse is dependent on ? Ca2+ NT’s are released by the ___synaptic and binds to ______ on the ____synaptic cell. Pre, receptors, and post
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Review: Synaptic events 1. Action potential invades terminal 2. Ca2+ floods the terminal 3. Neurotransmitters (NTs),i.e. chemical messengers, are released . 4. NTs diffuse across synaptic cleft. 5. NTs bind receptors 6. NTs disengage from receptors
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QUIZ #1
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ACH Learning Arousal
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NE Mood Arousal Sex
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5HT Mood Anxiety Sex Sleep
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The synapse on drugs Psychoactives Similar to endogenous chemicals Why ? Similar NTs among different species NTs also found in plants Widely varying effects
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THC
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Unformatted text preview: Lipid/Fat Soluble Remains in the body for weeks. Long lasting behavioral effects Euphoria Altered space time Disorientation Fatigue Appetite stimulation THC Binds to Cannabinoid receptors CB1 Nervous system CB2 Immune system Endogenous ligands 2-AG Anandimide AP Glu CB1 2-AG Anandimide Negative feedback Auto receptors Receptors located on presynaptic terminal bind released NT & slows release Postsynaptic signals NO 2 AG Anandamide Stimulants Temporarily increase alertness and attention Cocaine Amphetamine Adderall Dose and time course DA Distribution Stimulants Methamphetamine...
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This note was uploaded on 02/24/2011 for the course PSYC 460 taught by Professor Lawrence during the Spring '10 term at South Carolina.

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thesynapse1_29_2010bb - Lipid/Fat Soluble Remains in the...

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