5-Mutation Migration & Inbreeding

5-Mutation Migration & Inbreeding -...

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Evolutionary forces: Mutation Migration  Genetic Drift in small populations Non-random mating Selection
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Genomic mutation rates Organism Mutations per genome  replication Viruses .0001 - 1 Bacteria ~ .001 Plants and Animals ~ 1
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How are mutations produed? The Luria – Delbruck experiment: Selective media (LD selected for  resistance to T4  bacteriophage)
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The Luria – Delbruck experiment: If mutations are  induced  by encounter with T4 on  the plate, then every cell  will have an equal  probability of mutating to  resistance.
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The Luria – Delbruck experiment: If every cell has an equal  probability of mutating to  resistance, then the # of  resistant cells/plate can be  described using a  Poisson  distribution: Variance = Mean  
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Variance is much higher than  the mean. 
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The Luria – Delbruck experiment: If mutations occur  spontaneously  (i.e.  before selection is  applied) then we expect  greater variance in the  number of resistant  cells/plate.
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5-Mutation Migration & Inbreeding -...

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