8-Pre-mRNA processing-10-1

8-Pre-mRNA processing-10-1 - adjacent exons Fig. 8.16...

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Pre-mRNA Processing in Eukaryotes 11/05/10 Figures are taken from iGenetics by Russell or from the second edition of Molecular Biology by R. Weaver, or Genetics by Hartwell
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The general structure of mature mRNA in both prokaryotes and eukaryotes
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Fig. 18.2.c
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A methylated cap is added to the 5’ end of eukaryotic mRNAs Fig. 8.13
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3’ end processing of eukaryotic mRNA results in the addition of a poly-A tail Fig. 8.14
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Schematic diagram of eukaryotic 3’ end formation and poly(A) addition
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The human dystrophin gene: An extreme example of RNA splicing Fig. 8.15
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How RNA splicing splices out introns and joins
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Unformatted text preview: adjacent exons Fig. 8.16 Simplified mechanism of pre-mRNA splicing Outline of pre-mRNA splicing Fig. 8.27.a Fig. 8.27.b The process of splicing involves snRNPS Fig. 8.17 Small nuclear ribonucleoprotein particles (snRNPs) perform splicing reactions Five snRNPs (U1, U2, U4, U5, U6) Each consists of an snRNA and about 10 proteins snRNPs assemble on the pre-mRNA in a particular order Spliceosome = snRNP/pre-mRNA complex. The spliceosome cycle Fig. 8.18.a Alternative splicing Beta thalassemia Valolas et al. (2006) JBC 281, pp. 7399-7405...
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This note was uploaded on 02/24/2011 for the course BIOL 202 taught by Professor Kieber-hogan during the Fall '08 term at UNC.

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8-Pre-mRNA processing-10-1 - adjacent exons Fig. 8.16...

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