17-Posttranscriptional regulation-10

17-Posttranscriptional regulation-10 - Fig. 18.23 The Sxl...

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Post-transcriptional regulation: Alternative splicing RNA interference 12/03/10
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Sex-specific traits in Drosophila Fig. 18.20
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The X-chromosome:autosome ratio determines the sex phenotype in Drosophila
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Genetic studies identified genes that are important in male versus female differentiation and courtship behavior
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Fig. 18.16.a Two promoters control expression of the Sxl gene and the early promoter is active only in females.
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Molecular model to explain why the early promoter is active when the X:A ratio is 1 Fig. 18.21
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Fig. 18.16.b Sxl autoregulates splicing of Sxl transcripts that initiate at the late promoter in females.
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Fig. 18.22.a Sxl also regulates splicing of tra mRNA in females
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Fig. 18.22.b Tra regulates splicing of doublesex mRNA in females
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Female and male specific forms of Dsx regulate transcription of genes that are needed for female and male specific functions.
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Unformatted text preview: Fig. 18.23 The Sxl pathway also regulates expression of neuronal proteins that control sex-specific behaviors Fig. 18.24 RNA interference Small RNAs interfere with protein synthesis small interfering RNAs (siRNA)defense against RNA viruses and transposons micro RNAs (miRNA) involved in regulation of some genes that function during development RNAi has potential applications for treating incurable diseases. Post-transcriptional gene regulation by miRNAs and siRNAs: RNA interference Filiopowicz et al. (2005) 15 : 331-341 A simplified model for RNA interference (RNAi) R.A. Weaver, Molecular Biology, 4 th edition Fig. 18.17.a Fig. 18.17.b Fig. 18.18.a miRNA processing pre-miRNA pri-miRNA Two pathways to gene silencing by miRNAs R.A. Weaver, Molecular Biology, 4 th edition The development of RNAi therapy Page 671...
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This note was uploaded on 02/24/2011 for the course BIOL 202 taught by Professor Kieber-hogan during the Fall '08 term at UNC.

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17-Posttranscriptional regulation-10 - Fig. 18.23 The Sxl...

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