ANSintroforpdf2011-3

ANSintroforpdf2011-3 - 1 Introduction to Autonomic...

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Unformatted text preview: 1 Introduction to Autonomic Pharmacology Katzung: Chpt. 6 Cholinergic Drugs Katzung: Chpts. 7 & 8 & && Adrenergic Drugs Katzung Chpts. 9 &10 Only need to know drugs discussed in class Quiz and exam questions based on in-class discussions, posted notes and posted questions for assigned readings 1. Describe the anatomy and neurochemistry of the autonomic nervous system (ANS) 2. Name major receptor subtypes and probable At the end of this section you should be able to: receptor mediated action on effector tissue 3. Name and predict effects (including toxicities) of examples of cholinergic and adrenergic drugs. 4. Identify an unknown drug based on autonomic effects on organ systems. CNS BRAIN SPINAL CORD NERVOUS SYSTEM PNS AFFERENT EFFERENT CNS = central nervous system PNS = peripheral nervous system SNS CORD PSNS SOMATIC AUTONOMIC ENTERIC 2 & 1. PARASYMPATHETIC NERVOUS SYSTEM (PSNS) REST AND DIGEST 2. SYMPATHETIC NERVOUS SYSTEM (SNS) FIGHT OR FLIGHT Most organs receive input from both systems (exceptions: kidney, adrenal gland, sweat glands, pilomotor muscles, blood vessels) In general, PSNS and SNS mediate opposing responses in effector organ (physiological antagonists) central and peripheral components pre- and postganglionic fibers Preganglionic: brain and spinal cord to ganglia Ganglia = aggregation of cell bodies of postganglionic neurons Postganglionic: axons from ganglia to effector organs Innervates/regulates heart, blood vessels, glands, visceral organs H e art E y e B ro n c hi S t om a c h H e art E y e B ro n c hi S t om a c h S m a T 1 T 2 T 3 T 4 T 5 T 6 T 7 M id bra in M e d ul a L a c rim a l g lan t ds S a liv ary g la n d s S a liv ary g la n d s B lo o d v e s s els (h e ad & n ec k ) B lo od v e s s e ls (tru n k ) The Autonom ic Nervous System C 1 -7 C e rv ic a l g a ng lio n Parasym pathetic Sym pathetic C e lia c ga n glion H y po g a s tric p le x us S m a l In te s t in e A d re na l m e du l a K id ne y B la dd e r G en ita ls S t om a c h S m a l In te s tine A d re na l m e d ulla K id ne y B la dd e r G en ita ls T 8 T 9 T1 0 T11 T1 2 L 1 L 2 S 2 S 3 S 4 C o lo n C o lo n 3 && Leaves CNS via cranial and sacral nerves...
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ANSintroforpdf2011-3 - 1 Introduction to Autonomic...

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