Lab2_Biotech_2

Lab2_Biotech_2 - DNA as the Hereditary Material The first...

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1 DNA as the Hereditary Material • The first clue came from Griffith's discovery of transformation in Streptococcus pneumoniae . – Griffith found that heat-killed virulent S. pneumoniae cells could transform a nonvirulent strain to virulence. • What molecule within the heat-killed sample was carrying the information for virulence? • Avery, MacLeod, and McCarty set out to determine whether protein, DNA, or RNA was responsible for the transformation. – Cell extracts from heat-killed virulent S. pneumoniae were treated with enzymes that selectively degraded DNA, RNA, or protein. – The extracts were then tested to see if they could still transform nonvirulent cells to virulence. • Only extracts with intact DNA could transform cells to virulence, thus supporting the hypothesis that DNA is the hereditary material .
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2 The Hershey-Chase Experiment • Hershey and Chase studied how the T2 virus infects the bacterium Escherichia coli . • By radioactively labeling the virus's DNA with 32 P and its protein with 35 S, they demonstrated that DNA is the genetic material. DNA structure • DNA is composed of deoxyribonucleotides . • DNA is a polymer.
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This note was uploaded on 02/25/2011 for the course BIO 138 taught by Professor Wu during the Summer '08 term at Staten Island.

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Lab2_Biotech_2 - DNA as the Hereditary Material The first...

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