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DrugPart1 - Miracle drug In 1763 Edmund Stone an English...

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In 1763 Edmund Stone , an English clergyman, reported to the Royal Society the isolation of yellow, needle-shaped crystals from the bark of willow trees ( Salix alba ): sali cin • Mixture of two compounds: one of them helped reduce pain, fever and inflammation. Miracle drug • Side effects: very unpleasant taste, produced nausea and acute stomach irritation. Salicylic acid In 1898 , Felix Hoffmann, employee of a major German chemical firm, converted this compound into a different substance, which reverted back to the original once it was in the body, reducing the side effects in the stomach. - Very low toxicity - Remarkably effective antipyretic (fever reducing), analgesic (anti-pain), and anti- inflammatory agent. Miracle drug
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Salicylic acid + Acetic acid + H 2 O - works in the brain to reduce fever, - relieves inflammation in muscles and joints, - it apparently decreases the chances of stroke and heart attack. How Aspirin Works Aspirin blocks cyclooxygenase (COX-2) enzymes COX-2 are involved in the synthesis of prostaglandins .
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