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why%20we%20get%20sick - Why we get sick Darwinian medicine...

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1 Why we get sick: Darwinian medicine I. Adaptation, exquisite design, and sickness II. Proximate and ultimate explanations III. Genetic trade-offs A. Sickle cell anemia IV. Evolutionary legacies A. Malfunctional design flaws B. Life in the Stone Age V. Co-evolution of pathogens and hosts VI. Evolutionary insights into disease and health A. Modern day nutritional excesses B. Antibiotic resistance C. Fever D. Morning sickness Adaptation, exquisite design, & sickness Adaptation, exquisite design, & sickness Adaptation, exquisite design, & sickness Two questions Why hasn t natural selection : 1. weeded out the genes that make us susceptible to disease? 2. favored the evolution of genes that help us resist disease and sickness? Proximate vs. ultimate explanations Heart attacks: Eating fatty foods and having genes that predispose to atheroscelerosis are major causes of heart attacks. Proximate explanation
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2 Proximate vs. ultimate explanations Heart attacks: Ultimate explanation Why hasn’t natural selection eliminated the genes that promote craving for fat and cholesterol deposition? Proximate vs. ultimate explanations Proximate explanations : What & How questions about structure & mechanisms Ultimate explanations : Why questions about origins & functions Genetic trade-offs: sickle cell anemia Genetic trade-offs: sickle cell anemia Sickle cell anemia is caused by a single,
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