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Unformatted text preview: start- and stop-transfer signals give rise to the final arrangement. Eliminating the first start-transfer signal would not affect the function of the second transfer signal, which would initiate transfer of C-terminal segments just as it did in the unmodified, original protein. This conclusion is also reached by the fact that there are more than 100 amino acids at the N-terminus of the modified protein before the first transmembrane segment. The glycosylation sites near the N-terminus of the protein can only be modified if they are in the ER lumen. Thus, the mutant protein will not be glycosylated. Page 1 of 1...
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This note was uploaded on 02/27/2011 for the course BIO 320 taught by Professor Staff during the Spring '08 term at University of Texas at Austin.
- Spring '08
- cell biology