Discussion Section 3 - Secretory proteins are inserted with...

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Unformatted text preview: Secretory proteins are inserted with different orientations into ER--- Cooper 9.9 Insertion of a IMP that spans the membrane multiple times Cooper 9.13 See Alberts 12-48 STOP START STOP N C Cytosol ER Lumen ER sig. Seq. STOP START STOP START Cleavage site ER signal sequence is simply a start transfer sequence with a cleavage site right after it ER sig. Seq. SRP SRP SRPs are really only needed for start sequences to bring the ribosome to the ER translocon IN OUT IN OUT STOP START If there are more + charged amino acids before the signal then the N terminus will be in the cytosol and the signal will act as a start transfer START +++ The side with the most + charged amino acids will go in the cytosol START STOP N C START +++ OUT IN OUT IN Cytosol ER Lumen START STOP If there are more + charged amino acids after the signal then the N terminus will be threaded into the lumen of the ER and the signal will act as a stop transfer +++ The side with the most + charged amino acids...
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This note was uploaded on 02/27/2011 for the course BIO 320 taught by Professor Staff during the Spring '08 term at University of Texas at Austin.

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Discussion Section 3 - Secretory proteins are inserted with...

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