{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

Discussion Section 3 - Secretory proteins are inserted with...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
Secretory proteins are inserted with different orientations into ER--- Cooper 9.9
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Insertion of a IMP that spans the membrane multiple times Cooper 9.13 See Alberts 12-48
Background image of page 2
STOP START STOP N C Cytosol ER Lumen ER sig. Seq. STOP START STOP START Cleavage site ER signal sequence is simply a “start” transfer sequence with a cleavage site right after it ER sig. Seq. SRP SRP SRPs are really only needed for “start” sequences to bring the ribosome to the ER translocon IN OUT IN OUT
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
STOP START If there are more + charged amino acids before the signal then the N terminus will be in the cytosol and the signal will act as a “start” transfer START +++ The side with the most + charged amino acids will go in the cytosol START STOP N C START +++ OUT IN OUT IN Cytosol ER Lumen
Background image of page 4
START STOP If there are more + charged amino acids after the signal then the N terminus will be threaded into the lumen of the ER and the signal will act as a “stop” transfer +++ The side with the most + charged amino acids will go in the cytosol
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}