Lec9.2011.notes - Phagocytosis: Uptake of Particles...

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Lecture 9 Sorting at the TGN Exocytosis Endocytosis
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Clathrin Coated Vesicles Carry Man-6-Phosphate Receptor to pre-lysosomal Compartment
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AP-1 in Clathrin CV’s at the TGN; AP-2 in Clathrin CV’s at the Plasma Membrane TGN PM
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Three Distinct Vesicle Coats COP = coatomer protein Four! Five!
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Proteins carry SIGNALS for sorting to appropriate compartment EXCEPTION: Constitutive secretion. WITHOUT A SIGNAL, PROTEIN WILL FOLLOW SECRETORY PATH: ER ---> Golgi ---> Pl. Membrane
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Signals on Proteins Determine which Route from the TGN 13-64
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Two Basic Types of Exocytosis 13-63
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Signals on Proteins Determine which Route from the TGN 13-64
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Regulated secretion by a Mast cell: release of heparin and histamine from regulated secretory granules
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Figure 13-65a Molecular Biology of the Cell (© Garland Science 2008)
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Endocytosis: 1. Phagocytosis (cell eating) 2. Pinocytosis (cell drinking) a. Macropinocytosis (actin-mediated) b. Clathrin-mediated c. Caveolin-mediated
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Bon Appétit : Macrophage Are Professional Eaters pseudopods Macrophages eat 10 11 RBC’s per day!
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Unformatted text preview: Phagocytosis: Uptake of Particles Endocytosis: 1. Phagocytosis (cell eating) 2. Pinocytosis (cell drinking) a. Macropinocytosis (actin-mediated) b. Clathrin-mediated c. Caveolin-mediated Pinocytosis: Clathrin vesicles bring in fluid from the plasma membrane Clathrin-mediated Sorting Signals for Clathrin Coated Vesicles at the Plasma Membrane 1) A signal with a tyrosine 2) A di-leucine signal Receptor-Mediated Endocytosis: mediated by Clathrin 13-53 GOOD Receptor-Mediated Endocytosis: LDL receptor as an example The cytoplasmic tails of LDL Receptors have Tyrosine as part of signal to target the receptor to clathrin coated pits. AP2 13-51 GOOD BAD Receptor-Mediated Endocytosis: LDL receptor as an example 13-51 From the early endosome to the late endosome Movement from EE to LE along microtubules LE are converted to lysosomes with enough Vesicles bearing acid hydrolases 13-56 Endosomes form multivesiclar bodies: receptors within are mono-ubiquitinated See Alberts 13-57...
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This note was uploaded on 02/27/2011 for the course BIO 320 taught by Professor Staff during the Spring '08 term at University of Texas at Austin.

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Lec9.2011.notes - Phagocytosis: Uptake of Particles...

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