Lecture5.2011.notes

Lecture5.2011.notes - Membrane Traffic *Secretory Traffic...

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon
Membrane Traffic ** Secretory Traffic Endocytic Traffic
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Fig 12-40
Background image of page 2
Fig 12-40
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Free vs. bound ribosomes How do “bound” ribosomes bind the RER?
Background image of page 4
Signal Sequences Alberts, 2002
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
ER  Signal sequence of Growth Hormone:  Targeting Signal to the  RER Cooper 9.6 Most ER signal sequences: an amino-terminal stretch of nonpolar (hydrophobic) residues accompanied by basic residues (e.g. Arg.) Other examples:
Background image of page 6
Signal Recognition Particle (SRP) 6 protein subunits of which one has GTPase activity, 1 small RNA subunit See Alberts 12-39
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
• Multimeric protein complex that creates an aqueous channel in the ER membrane • Permeability has to be tightly regulated--> plug • conserved mechanism The translocon
Background image of page 8
A secreted protein --nascent peptide to the RER Alberts 12-40 1. Signal peptide emerges - binds SRP Translation STOPS
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
A secreted protein --nascent peptide to the RER 2. Attachment of the Ribosome to the ER: SRP-receptor + Translocon Fig 12-40
Background image of page 10
A secreted protein --nascent peptide to the RER 1. The signal peptide binds the translocon 2. the channel opens Alberts 12-40
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
A secreted protein --nascent peptide to the RER 4. SRP is released from the receptor 5. Polypeptide translocates through the channel Alberts 12-40
Background image of page 12
A secreted protein --nascent peptide to the RER: Signal peptidase cleaves Alberts 12-45
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 14
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 02/27/2011 for the course BIO 320 taught by Professor Staff during the Spring '08 term at University of Texas.

Page1 / 30

Lecture5.2011.notes - Membrane Traffic *Secretory Traffic...

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online