Lecture6.2011.handout - Lecture 6 How vesicles function in...

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Lecture 6 How vesicles function in Membrane Traffic: Coated vesicle formation
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Secretory proteins are inserted with different orientations into ER--- Cooper 9.9
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Internal noncleavable signal sequences : serves as both a signal sequence for binding SRP and a start- transfer sequence for insertion into membrane. (Note: positive CHARGE’s dictate direction ) An IMP with the N-terminus on the cytosolic side of the RER Alberts 12-47
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Flanking Positive charge --> goes to cytosolic Can actually FLIP (!!!) internal signal seq. In translocon!!!! Alberts 12-47 An IMP with the N-terminus on the luminal side of the RER
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Insertion of a Integral Membrane Protein that spans the membrane multiple times Alberts 12-49
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Three Basic Players : Donor membrane, Target Membrane, and Transport Vesicle Fig 13-2
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Three Distinct Vesicle Coats COP = coatomer protein
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Vesicle budding accomplished by COATS that surround vesicles COATS: peripheral membrane protein function as: a mechanical device that can bend and curve a vesicle,
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Lecture6.2011.handout - Lecture 6 How vesicles function in...

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