lecture 9

lecture 9 - Signal Transduction Neurons receive signals...

Info iconThis preview shows pages 1–14. Sign up to view the full content.

View Full Document Right Arrow Icon
Signal Transduction Neurons receive signals from other neurons (neurotransmitters) and other cells (hormones, growth factors, and trophic factors). They have specialized machinery that can transduce these signals to changes in their physiological state. Neurons can change their state (ie. which receptors, channels, neurotransmitters, etc they want to open, modulate or express) depending on what they perceive is going on in their environment.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Different types of cell-cell communication • Endocrine signaling- secretion of hormones into the blood stream • Paracrine signaling- acts over a short range • Synaptic signaling • Membrane protein signaling-two cells next to each other signal through membrane proteins • Autocrine signaling-cell talks to itself
Background image of page 2
Endocrine Signaling
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Paracrine Signaling
Background image of page 4
Autocrine Signaling
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Signaling by Membrane Proteins
Background image of page 6
Components of signaling • Signal
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Three classes of signaling molecules
Background image of page 8
Components of signaling Signal Receptor- the way to sense a signal.
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Types of receptors Channel linked receptors: example the ACh receptor, signal is neurotransmitter; depolarization is signal, Na+ channel is target. G-protein coupled receptors: signal through trimeric G- proteins. The proteins can alter the function of many proteins. Enzyme linked receptors usually signal through protein kinases or protein phosphatases. Protein modiFcation then alters intracellular enzyme activity. Intracellular receptors- hormone receptors -signal binds directly to an intracellular protein which then activates transcription.
Background image of page 10
Categories of Cellular Receptors
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Categories of Cellular Receptors
Background image of page 12
Components of signaling Signal Receptor- the way to sense a signal. Target molecules that mediate the cellular response.
Background image of page 13

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 14
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 46

lecture 9 - Signal Transduction Neurons receive signals...

This preview shows document pages 1 - 14. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online