Haines-9

Haines-9 - Gene Mutation, DNA repair and Transposition...

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Gene Mutation, DNA repair and Transposition
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Genetic Techniques, Cell Culture, and Pedigree Analysis Are All Used to Detect Mutations Nutritional mutations in Neurospora crassa are detected by growth on complete medium or supplemental minimal medium versus no growth on minimal medium. Prototrophs will grow on minimal medium, but auxotrophs require a specific supplement to the minimal medium. Many genetic mutations in plants can be detected by direct visual observation or by determining the plant's biochemical composition.
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Pedigree analysis is used to determine the mutational basis for a human characteristic or disorder Dominant mutations: Present on X -pass on to all daughters Autosomal -approximately 50% of offspring will harbor defect
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Recessive mutations: Victoria (female carrier) passed on X-linked recessive hemophilia mutation to son and males of subsequent generations Autosomal recessive-a mating between an affected individual and a homozygous normal will produce unaffected carrier children. Mating between two carriers will produce on average 25% affected offspring
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of Compounds The Ames test uses four sensitive strains (defective in genes in excision repair and and lipopolysaccharide barrier) of Salmonella typhimurium selected for their sensitivity to specific types of mutagenesis to screen compounds for potential mutagenicity
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Haines-9 - Gene Mutation, DNA repair and Transposition...

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