Lecture_14-2011 - Genetics and Genomics Forward genetics...

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Genetics and Genomics Forward genetics Reverse genetics Genetic tools for genome-wide analysis Genome scale reverse genetics Signature tagged mutagenesis Synthetic lethal screens Book - 300-304 (mid-page), 306-307, 310 Gain-of- function, 317 synthetic lethal screens
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Brief review of genetic terms Types of mutations Null mutations (Amorph) - loss of function Hypomorphs - partial loss of function Hypermorphs - gain of function Antimorphs - dominant negative Neomorphs - generation of a new function
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Essential and non-essential genes What does it mean to be essential? Genes essential for growth in the laboratory Genes not essential for growth in the laboratory can be essential in other conditions.
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Isolating mutants that confer a particular phenotype and then identifying the genes involved. Sporulation defects. Temperature sensitive mutations.
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This note was uploaded on 03/01/2011 for the course MMG 433 taught by Professor Britton,r during the Spring '08 term at Michigan State University.

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Lecture_14-2011 - Genetics and Genomics Forward genetics...

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