{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

c13_cont_mod - Modeling signal transduction networks by...

Info icon This preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Modeling signal transduction networks by continuous and deterministic models Receptor - ligand binding - assumed to be elementary reaction Methylation, phosphorylation reactions – catalyzed by enzymes, Michaelis-Menten kinetics assumed Dephosphorylation, protein degradation – spontaneous or catalyzed Protein synthesis –catalyzed by mRNA St D i t t i l d Steps: Designate one component as signal and one as response; Write rates of change for the concentration of components based on the interactions they participate in; based on the interactions they participate in; Find steady state concentrations; Determine the dependence of the steady state response on the signal strength.
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon