C13_cont_mod - Modeling signal transduction networks by continuous and deterministic models Receptor ligand binding assumed to be elementary

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Modeling signal transduction networks by continuous and deterministic models Receptor - ligand binding - assumed to be elementary reaction Methylation, phosphorylation reactions – catalyzed by enzymes, Michaelis-Menten kinetics assumed Dephosphorylation, protein degradation – spontaneous or catalyzed Protein synthesis –catalyzed by mRNA Steps: Designate one component as signal and one as response; Write rates of change for the concentration of components ased on the interactions they participate in; based on the interactions they participate in; Find steady state concentrations; Determine the dependence of the steady state response on the signal strength.
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The signal acts on R both directly, and through an intermediary. S is assumed to work at saturation (plentiful substrate). The catalyzed ecay is assumed to be elementary Steady state: decay is assumed to be elementary. Steady state: R X k S k t dR 2 1 = 3 S k X SS = dt 4 k X k S k dt dX 4 3 = 3 2 4 1 k k k k R SS = The steady state response does not depend on the signal. Excitation- adaptation response to step changes
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C13_cont_mod - Modeling signal transduction networks by continuous and deterministic models Receptor ligand binding assumed to be elementary

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