c13_cont_mod_handout - Modeling signal transduction...

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1 Modeling signal transduction networks by continuous and deterministic models Receptor - ligand binding - assumed to be elementary reaction Methylation, phosphorylation reactions – catalyzed by enzymes, Michaelis-Menten kinetics assumed Dephosphorylation, protein degradation – spontaneous or catalyzed Protein synthesis –catalyzed by mRNA Steps: Designate one component as signal and one as response; Write rates of change for the concentration of components based on the interactions they participate in; Find steady state concentrations; Determine the dependence of the steady state response on the signal strength. The signal acts on R both directly, and through an intermediary. S is assumed to work at saturation (plentiful substrate). The catalyzed decay is assumed to be elementary. Steady state: Incoherent feed-forward loop R X k S k dt dR 2 1 = 4 3 k S k X SS = X k S k dX = 4 1 k k R The steady state response does not depend on the signal.
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This document was uploaded on 03/01/2011.

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c13_cont_mod_handout - Modeling signal transduction...

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