Day_Lecture_8b

Day_Lecture_8b - Chapter 8 ctd 9. Reaction of oxirane with...

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Chapter 8 – ctd 9. Reaction of oxirane with organometallic reagents Just as H can serve as a nucleophile in reactions with oxirane organometalic reagents also react with these substrates: or The strength of the Grignard or organo lithium “carbon nucleophile” can be gauged by the fact that OH , a very poor leaving group (!) is replaced in these reactions. Please, note that the above examples do not address the sterioc outcome of these reactions. This will be covered (soon) in a later chapter. Stay tuned. 10. Applying reactions to synthesis The synthesis of specific target materials requires that we carry out reactions at a specific center without affecting any other segment of the molecule. Carrying out a synthesis requires careful planning and consideration of many factors, such as cost, availability, efficiency and yield, the toxicity of potential byproducts, and many others. We have learned a few specific reactions. For example, only one of
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This note was uploaded on 04/04/2008 for the course CHEM 307 taught by Professor Several during the Spring '08 term at Rutgers.

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Day_Lecture_8b - Chapter 8 ctd 9. Reaction of oxirane with...

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