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chp20 - Ch 20 Immune 1 Explain the differences between the...

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Ch 20 Immune 1. Explain the differences between the innate (non-specific) and adaptive (specific) immune system including what cells and processes are unique to each and any shared components. 2. List the components of the first line of defense of the innate immune system. 3. Describe when the second line of defense of the innate immune system is activated and the inflammation response. 4. List the 4 phases of phagocyte mobilization in inflammation. 5. Describe the antibody-mediated (humoral) immune response and cell- mediated immune response. 6. Define active and passive humoral immunity and naturally and artificially acquired immunity. 7. Explain the roles of B cells and T cells in immune responses. http://nobelprize.org/medicine/educational/immunity/immune-detail.html
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Innate (non-specific) Immune System -Quick response 1. First Line of Defense Very effective if not broken Physical barriers: Skin and mucosae Chemical barriers: acid pH of skin, vaginal secretions, stomach secretions, mucous in digestive and respiratory tracts, enzymes in tears, antibiotics in sweat 2. Second Line of Defense Inflammatory response and the cells and chemicals associated with it.
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Innate Immune System Cells (Second Line of Defense) Phagocytes: Have receptor that recognizes certain classes of pathogen Monocyte--Macrophage Some stay in certain tissues (fixed) and others move around http://www.wisc-online.com/objects/index_tj.asp?objID=AP12304 Neutrophil or Esonophil
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Innate Immune System Cells (Second Line of Defense) Natural Killer Cells Large lymphocytes that kill cells that do not contain self surface antigens Release perforins that create a hole in the membrane and cause cell death Cancer cell Virus infected cell Natural Killer Cell perforins
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Inflammatory Response (Second Line ) Symptoms: Damaged tissues Inflammatory Chemicals Fluid Increased Permeability and Vasodilation
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Leukocytosis Margination Diapedesis Chemotaxis Neutrophils enter blood from bone marrow 1 2 3 4 Margination Diapedesis Positive chemotaxis Capillary wall Endothelium Basal lamina
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