B-DEPRESSION2011-A-publish.key

B-DEPRESSION2011-A-publish.key - Antidepressants PMY...

Info iconThis preview shows pages 1–9. Sign up to view the full content.

View Full Document Right Arrow Icon
PMY 406/512/516 Spring 2011 Antidepressants
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Symptoms of Depression Insomnia Poor appetite, weight loss Fatigue, loss of energy Agitation Loss of interest Feelings of helplessness, worthlessness Diminished ability to think or concentrate Thoughts of death or suicide
Background image of page 2
Non-familial (75%) Associated with stressful life events Accompanied with anxiety, agitation Familial pattern (25%) Unrelated to external stresses Different symptomatology Unipolar depression Reactive depression Endogenous depression } } Do drugs show selectivity between the 2 types? Mood swings in same direction
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Bipolar disorder Depression alternates with mania excessive exuberance self-confidence impulsive actions impatience aggression grandiose delusions As with depression, mood and actions in manic episodes are inappropriate to the circumstances
Background image of page 4
Monoamine oxidase inhibitors Tranylcypromine (Parnate) Phenelzine (Nardil) SNRIs Duloxetine (Cymbalta) Venlafaxine (Effexor) Desvenlafaxine (Pristiq) SSRIs Escitalopram (Lexapro) Citalopram (Celexa) Paroxetine (Paxil) Fluoxetine (Prozac) Sertraline (Zoloft) Tricyclic antidepressants Imipramine (Tofranil) Doxepin (Sinaquan) Amitriptyline (Elavil) Serotonin receptor antagonists Trazodone Nefazodone Bupropion (Wellbutrin )
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Therapeutic utility of antidepressants Depression Anxiety disorders Pain disorders Autism Binge-eating disorders Insomnia OCD
Background image of page 6
Issues Clinical diagnosis of depression “Switch” phenomena Therapeutic lag Risk of suicide
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Molecular effect Monoamine neurotransmission Clinical application Reserpine Inhibits storage of monoamine neurotransmitters Decreased Schizophrenia Chlorpromazine Acts as a dopamine receptor antagonist Decreased Schizophrenia Iproniazid Inhibits monoamine oxidase Increased Depression Imipramine Inhibits synaptic uptake
Background image of page 8
Image of page 9
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 03/06/2011 for the course PMY 406 taught by Professor Berman during the Spring '11 term at SUNY Buffalo.

Page1 / 30

B-DEPRESSION2011-A-publish.key - Antidepressants PMY...

This preview shows document pages 1 - 9. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online