Dopamine SystemsPart-i(1)

Dopamine SystemsPart-i(1) - PHARMACOLOGY OF DOPAMINE...

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PHARMACOLOGY OF DOPAMINE SYSTEMS JAN. 26 & 28 - CHAPTER 12, GOLAN 1 1
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Dopaminergic Transmission 2 2
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Dopamine Synthesis 3 3
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4 Catecholamine Metabolism 4
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5 Dopamine Receptors Excitatory; basal ganglia function, memory and performance Inhibitory; decreases dopamine release, reduces firing of neurons 5
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6 Dopamine Receptor Location 6
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7 Central Dopamine Pathways 7
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8 Sites of Action of Anti-Psychotic Agents 8
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9 Mechanisms of Action of Anti- Psychotic Agents 9
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10 Antipsychotic Drug Potency And Dopamine D2 Receptor Binding 10
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Mechanism Therapeutic Effects Adverse Effects Blockade of α 1 - adrenoceptors - Dizziness, orthostatic hypotension, and reflex tachycardia Blockade of dopamine D 2 receptors Alleviation of positive symptoms of schizophrenia Extrapyramidal effects (akathisia, dystonia, and pseudoparkinsonism) and elevated serum prolactin levels Blockade of dopamine D 4 receptors Alleviation of negative symptoms of schizophrenia and decrease in the
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This note was uploaded on 03/06/2011 for the course PMY 406 taught by Professor Berman during the Spring '11 term at SUNY Buffalo.

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Dopamine SystemsPart-i(1) - PHARMACOLOGY OF DOPAMINE...

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