Serotonin-1per

Serotonin-1per - SEROTONERGIC & CNS ADRENERGIC...

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Unformatted text preview: SEROTONERGIC & CNS ADRENERGIC PHARMACOLOGY Feb. 12 Chap. 13 Golan (& Chap 9 for review of Adrenergics) 1 2 Regulation of Serotonin Transmission 2 3 Noradrenergic Synapse 3 4 Serotonin Synthesis Norepinephrine Synthesis 4 5 Monoamine Transporter Family 5 6 Serotonin Degradation 6 7 Serotonin Receptors Receptor Subtype Signaling Electrophysiological Response 5-HT 1 (A, B, D , E, F) (alpha 2 adrenergic) cAMP Increase K+ conductance; hyperpolarize 5-HT 2 (A, B, C) (alpha 1 adrenergic) IP3 & DAG Decrease K+ conductance; slow depolarize 5-HT 3 (ionotropic) Ion channel Na+ conductance; fast depolarize 5-HT 47 cAMP, or IP3 & DAG Decrease K+ conductance; slow depolarize 7 8 Serotonin & NE Pathways 5-HT Esp. from Raphe Nuclei to Spinal Cord: Pain Visceral regulation Motor control to Forebrain: Mood Cognition Neuroendocrine NE Esp. from Locus coeruleus Vigilance Stress response Neuroendocrine Pain Sympathetic outflow 8 9 Serotonergic (& Noradrenergic) Drugs Anti-depressants Hypnotics Migraine GI: (Irritable Bowel Syndrome) 9 10...
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Serotonin-1per - SEROTONERGIC & CNS ADRENERGIC...

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