cells12-signaling2-2009

cells12-signaling2-2009 - Bio 106 Cells Lecture 12...

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Unformatted text preview: Bio 106 Cells Lecture 12 10/3/2009 Professor Owen Fall 2009 1 Signaling Responses Signaling Responses ECB 3 16-7 G-protein Receptors protein Receptors N-terminus in extracellular space C-terminus in cytoplasm 7 tran -membrane Hormone binds here 7 trans membrane -helices G-protein interacts with 3rd loop in the cytoplasm COO- Modified from ECB 3 16-16 ECB 2 16-14 G-proteins proteins Binding of a signal to the receptor changes its shape, which in turn alters the conformation of the G-protein that is bound to it. The change in shape of the G-protein allows the -subunit to exchange its GDP for GTP Modified from ECB 2 16-17 G-protein Cycle protein Cycle 1. Bound to GDP (OFF) 2. Transient empty state 3. Bound to GTP (ON) Cycle with 3 stages: Cycle with 3 stages: ECB 2 16-15B Anchored with lipid tails to PM ECB 3 16-17 G Has GTPase Activity Has GTPase Activity GTP GTP (but GTPase activity (but GTPase activity can be inhibited, ie. can be inhibited, ie. can be inhibited, ie....
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This note was uploaded on 03/03/2011 for the course BIO 106 taught by Professor T.pageowen during the Spring '11 term at Conn College.

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cells12-signaling2-2009 - Bio 106 Cells Lecture 12...

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