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zhao BIO310 LEC06 - Plasma Membrane Chapter 13 The Plasma...

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2 3 7 5 6 4 1 10 9 8 Plasma Membrane Chapter 13: The Plasma Membrane P529-P565
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Structure of Plasma Membrane Lipid Bilayer Proteins - Forms a stable barrier between two aqueous compartments; - Impermeable to water-soluble mole- cules including ions and most biological molecules; - The bilayer lipids are mobile, not solid. - Selective transport of molecules; - Cell-cell, Cell/Matrix interactions; - Cell signaling. Fluid mosaic model
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Lipid Bilayer PS PI PE PC SM - + Outer leaflet : SM & PC, Glyco- Lipid, cholesterol Inner leaflet : PS & PE, PI, cholesterol The outer leaflet and inner leaflet are asymmetrical Phospholipid Sphingomyelin - SM Phosphatidylcholine - PC Phosphatidylserine - PS Phosphatidylethanolamine - PE Phosphatidylinositol - PI
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Phospholipids - Account for more than half of the lipid in most membrane; - Responsible for the basic function of membranes as barriers; - The long fatty acid chains can move freely in the interior of the membrane.
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Glycolipids - Constitute about 2% of the lipids of most plasmas membrane; - Exclusively in the outer leaflet; - Its carbohydrate portions exposed on the cell surface play protective role, as well as involved in cell-cell recognition.
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Cholesterol - A major constituent of animal cell membrane: about equal molar amounts as the phospholipids; - It fills the gap between kinked long fatty acid chains; Help control membrane fluidity: at high Tm, reduces membrane mobility and permeability; at low Tm, prevents membrane from freezing.
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Synthesis of Phospholipid - All major lipids of eukaryotic mem- branes are synthesized by the smooth ER or Golgi; - Phospholipids are synthesized from water soluble cytosolic precursors on the cytosolic side of the ER memrane; - New phospholipids are added only to the cytosolic half of the ER membrane; - Smooth ER is also the major site for the synthesis of Cholesterol and Ceramide. Ceramide is converted to glycolipids or sphingomyelin.
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