Chapter 5 part 4_Spr11 - phosphodiester bond phosphodiester...

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Nucleic Acids Chapter 5 (Pages 86 – 89)
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1 2 3 Synthesis of mRNA in the nucleus Movement of mRNA into cytoplasm via nuclear pore Synthesis of protein NUCLEUS CYTOPLASM DNA mRNA Ribosome Amino acids Polypeptide mRNA
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The chemical composition The chemical composition of DNA of DNA polymer polymer , made of repeating units units are nucleotides nucleotides nitrogenous base base deoxyribose sugar phosphate phosphate group
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Each polynucleotide Consists of monomers called nucleotides Nitrogenous base Nucleoside O O O - - O P CH 2 5’C 3’C Phosphate group Pentose sugar (b) Nucleotide O
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Assembly into a Nucleotide : Assembly into a Nucleotide : Linkage N-1 to C-1’ Linkage N-9 to C-1’ Base and Sugar Base and Sugar Base + sugar + phosphate
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Nucleotides polymerize via phosphodiester linkage
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linkage between nucleotides consists of a phosphate group linked to 2 sugars through a
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Unformatted text preview: phosphodiester bond phosphodiester bond gives DNA polarity polarity always a free 5-PO 4 2-and a free 3-OH end 5-end 3-end A C G A T C Oligonucleotide Polynucleotide DNA is double-stranded, with c omplementary base pairing . Fig. 5-UN2a SUMMARY Fig. 5-UN2b IMPORTANT concepts What is the relation between DNA, RNA, proteins? What is the difference between nucleosides and nucleotides? How do these differ between DNA and RNA? What is the structural difference between the sugar in a DNA as against in an RNA molecule? Be able to identify these sugars. Be able to write complementary DNA and RNA sequence with correct polarity Chapter 5 concepts Concept check: 5.1, 5.2, 5.4...
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Chapter 5 part 4_Spr11 - phosphodiester bond phosphodiester...

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