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1408 Ch 12 Outline-1 - 12 DNASTRUCTURE ANDFUNCTION...

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12 DNA STRUCTURE AND FUNCTION Chapter Outline IMPACTS, ISSUES: HERE KITTY, KITTY,  KITTY 12.1 THE HUNT FOR FAME, FORTUNE, AND  DNA Early and Puzzling Clues Confirmation of DNA Function Enter Watson and Crick 12.2 THE DISCOVERY OF DNA’S  STRUCTURE DNA’s Building Blocks Patterns of Base Pairing 12.3 FAME AND GLORY 12.4 REPLICATION AND REPAIR How DNA Gets Copied Checking for Mistakes 12.5 USING DNA TO DUPLICATE EXISTING  MAMMALS SUMMARY SELF-QUIZ CRITICAL THINKING Objectives 1. Understand how experiments using bacteria and viruses demonstrated that instructions for producing  heritable traits are encoded in DNA. 2. Describe the building blocks of DNA and recognize proper base pairing. 3. Describe the structure of a DNA molecule. 4. Understand how DNA is replicated and repaired. 5. Understand various ways that mammals can be cloned and the implications of such cloning. Key Terms adenine bacteriophages cloning cytosine deoxyribonucleic acid  (DNA) deoxyribose DNA ligases DNA repair mechanisms DNA replication DNA polymerases double helix guanine nucleotides semiconservative thymine x-ray diffraction images DNA Structure and Function 102
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Lecture Outline Impacts, Issues: Here Kitty, Kitty, Kitty A. Dolly was the first cloned mammal. 1. This lamb was identical to the one from which the donor cell had been taken; she had no  father’s contribution of genes. 2. Dolly aged prematurely; her chromosomal telomeres were as short as the six-year-old  animal from which she had been cloned. B. Cloning mammals is difficult. 1. Not many nuclear transfers are successful; most individuals die before birth or shortly  thereafter.
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