Integumentary System

Integumentary System - The Integumentary System Biol 1334...

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The Integumentary System Biol 1334 Lecture 9
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Skin and its derivatives Skin composed of two regions – Epidermis Outermost layer Composed of epithelial cells Avascular – Dermis Underlying layers Composed of connective tissue Vascular Subcutaneous layer called the hypodermis – Not technically part of the skin Anchors the skin to underlying structures Acts as a shock absorber & insulator
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Four cell types of epidermis Keratinocytes Melanocytes Langerhans’ cells Merkel cell
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Keratinocytes Produce keratin (fibrous protein that forms intermediate filaments) that provide the protective properties to the skin Tightly connected to one another by desmosomes Arise in the deepest layers and push towards the surface At the surface they are dead cells – scalelike structures full of keratin
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Melanocytes Synthesize the pigment of melanin Located in the deepest layer Have long spiderlike processes Melanin granules are taken up by keratinocytes & accumulate on the superficial side of the nucleus to protect the nucleus from UV light
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And the rest… Langerhans’ cells Immune cell arising from the bone marrow Phagocytic – ingest foreign substances Merkel cells Located at the dermal-epidermal boundary Associated with nerve endings In combination with nerve endings = sensory receptor for touch
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Five layers of the epidermis Outside to Inside Stratum corneum Stratum lucidium Stratum granulosum Stratum spinosum Stratum basale
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Stratum basale Deepest layer Attached to the underlying dermis Consists of a single row of continually renewing keratinocytes (youngest) 10-25% cells = melanocytes Small minority of cells = Merkel cells
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Stratum spinosum Overlies the stratum basale Several layers thick Contains webs of intermediate filaments in cells to resist tension Keratinocytes have a “spiny” appearance Contains Langerhans’ cells
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This note was uploaded on 03/06/2011 for the course BIOL 1334 taught by Professor Chadwayne during the Spring '08 term at University of Houston.

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Integumentary System - The Integumentary System Biol 1334...

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