Blood&Immunity27March08

Blood&Immunity27March08 - What are the functions of...

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1 What are the functions of blood? Transportation Regulation Defense Maintain Homeostasis What is blood made of? Liquid Component Cellular Component Plasma Blood cells & Platelets Plasma 55% of tot. vol. - 90% water - ions - proteins albumin fibrinogen IGgs lipoproteins Plasma Serum: plasma with the blood clotting proteins removed
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2 All blood cells and platelets originate from stem cells Stem cells Immature bcs Mature bcs erythrocytes Leukocytes Platelets Erythrocytes (red blood cells) Carriers Biconcave No nucleus Leukocytes (white blood cells) Defense Phagocytes Monocyte Neutrophil Eosinophils Eosinophil Basophils Basophil Lymphocytes Lymphocyte
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3 Platelets Cell fragments No nuclei Clotting How do clots form ? Blood Clotting Vessel Constriction Platelet plug Permanent clot (complex process) Summary I. Plasma II. Cellular components A. Erythrocytes B. Leukocytes 1. Phagocytes a. Monocytes b. Neutrophils 2. Eosinophils 3. Basophils 4. Lymphocytes III. Platelets
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4 The Immune System Body under constant attack by: How do we defend ourselves ? Distinguish Self from Non-self Defense can be Specific or Non-specific Three lines of DEFENSE
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5 Lymphatic System Leukocytes (white blood cells) Defense Phagocytes Monocyte Neutrophil Eosinophils Eosinophil Basophils Basophil Lymphocytes Lymphocyte B cells T cells Figure 43 Figure 43 -1 Page 833 Page 833 Rapid PATHOGENS INVADE TISSUES Require several days NONSPECIFIC (INNATE) IMMUNE RESPONSES SPECIFIC (ADAPTIVE) IMMUNE RESPONSES Physical barriers Soluble molecules Phagocytosis Inflammation Cell- mediated immunity Antibody- mediated immunity Skin; mucous lining of digestive, respiratory, and urinary tracts Cytokines (interleukin, interferons, tumor necrosis factors) Complement First line of defense
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6 Figure 43 Figure 43 -1 Page 833 Page 833 Rapid PATHOGENS INVADE TISSUES Require several days NONSPECIFIC (INNATE) IMMUNE RESPONSES SPECIFIC (ADAPTIVE) IMMUNE RESPONSES Physical barriers Soluble molecules Phagocytosis Inflammation Cell- mediated immunity Antibody- mediated immunity Skin; mucous lining of digestive, respiratory, and urinary tracts Cytokines (interleukin, interferons, tumor necrosis factors) Complement Second line of defense Histamine Inflamatory response Figure 43 Figure 43 -1
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Blood&Immunity27March08 - What are the functions of...

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