O2 consumption curve

O2 consumption curve - (d) Succinate overrides the rotenone...

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(b) (c) (d) (e) (f) Time (a) The NADH provides electrons as fuel for ATP synthesis. Therefore the overall oxygen concentration decreases because oxygen consumption is slowly beginning to increase. (b) The ADP can be converted to ATP via the electrons from NADH. Thus oxygen concentration decreases rapidly. (c) Rotenone inhibits complex I causing oxygen consumption to cease
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Unformatted text preview: (d) Succinate overrides the rotenone inhibition allowing electrons to enter at complex II. Thus, oxygen consumption will again increase. (e) As ADP runs out oxygen consumption will slowly decreases (f) DNP will uncouple oxidative phosphorylation and electron transport. This will continue to dissipate the gradient and increase oxygen consumption....
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