chapter48%20-%20endocrine%20regulation%20_1_%20online

chapter48%20-%20endocrine%20regulation%20_1_%20online -...

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Hormonal Regulation Chapter 48 Endocrine hormone molecules are secreted (released) directly into the bloodstream (ductless) Exocrine hormones (or ectohormones) are secreted directly into a duct, and from the duct they either flow into the bloodstream or they flow from cell to cell by diffusion in a process known as paracrine signaling
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Types of Hormonal Signaling (Fig 48-3) neurotransmitters
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Eicosanoids are polyunsaturated fatty acid derivatives…… Arachadonic acid: most abundant precursor : Juvenile hormone A prostaglandin Hormone Groups Fig 48-2a
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Steroid hormones Lipids; derivatives of cholesterol, diffuse across cell membranes. Molting hormone (ecdysone) Cortisol Estradiol (principal estrogen) Hormone Groups Fig 48-2b
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Amino acid derivatives Hormones derived from the amino acid tyrosine : Thyroid hormones Catecholamines Hormones derived from the amino acid tryptophan: Serotonin and the pineal hormone melatonin Norepinephrine Epinephrine Thyroxine (T 4 ) Triiodothyronine (T 3 ) Hormone Groups (Fig 48-2c)
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Peptide and Protein Hormones Peptide hormones packaged into secretory vesicles for export: Regulated secretion: Constitutive secretion: Many protein hormones: synthesized as prohormones; proteolytically clipped to generate mature, active form Oxytocin ADH Hormone Groups Fig 48-2d
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Local Regulators – Paracrine and Autocrine Some are considered hormones; use autocrine and paracrine signaling Growth factors (paracine, autocrine) Prostaglandins (paracrine) Neurotransmitters (paracrine) neurological
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Endocrine Regulators: Steroid and Thyroid Hormones (Fig 48-4) Hormone: free vs bound to plasma proteins
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Hydrophilic Hormones G-linked receptors and cAMP
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Hydrophilic Hormones G-linked receptors and IP3 and DAG
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Hydrophilic Hormones Enzyme-linked receptors NB: EGF Dimerization
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Insect Hormones (Fig 48-6) Environmental factor?
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Human Endocrine and Neuroendocrine Glands (Fig 48-7), Table 48-1
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This note was uploaded on 03/08/2011 for the course BIO 119 taught by Professor Transue during the Spring '09 term at Rutgers.

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chapter48%20-%20endocrine%20regulation%20_1_%20online -...

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