11.RegulationII.ppt

11.RegulationII.ppt - NS120 -Molecular Toxicology...

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NS120 -Molecular Toxicology Xenobiotic Nuclear Receptors Phenobarbital crystals
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Learning Objectives 1. Name a few orphan receptors. How were they identified? 2. How does the position of a response element affect induction of gene expression? 3. Describe the general mechanism of how orphan receptors induce gene expression. 4. What are some of the techniques used to identify response elements in the promoters of genes? 5. What are the targets of orphan receptors? What roles do these targets play in the life of a xenobiotic? 6. What is meant by l cross-talk z and how does it affect gene expression?
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Readings Î Orphan Nuclear Receptors: The Exotics of Xenobiotics, THE JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 276, pp. 37739–37742, 2001 Î P450 Gene Induction by Structurally Diverse Xenochemicals: Central Role of Nuclear Receptors CAR, PXR, and PPAR1 Archives of Biochemistry and Biophysics Vol. 369, pp. 11–23, 1999 Online Resource - http://bc.georgetown.edu/nrr/nrr.html
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11.RegulationII.ppt - NS120 -Molecular Toxicology...

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