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Unformatted text preview: 1 M o l e c u l a r T o x i c o l o g y T O X I C o- G e n o m i c s P r e d i c t i o n P h a s e I Phase II Mechanisms Of Toxicity Exposure Absorption Distribution Metabolism Molecular Target Cell Damage Organ Toxicity Organism C a r c i n o g e n e s i s In vitro I n d i v i d u a l V a r i a t i o n T o x i c a n t s X e n o b i o t i c s NS 120/220 NS 120/220 Molecular Toxicology Molecular Toxicology Chris Vulpe Chris Vulpe vulpe vulpe @berkeley berkeley .edu edu 642-1834 642-1834 317 Morgan Hall 317 Morgan Hall 2 Objectives/Goals Expected Background Lectures Reading Textbooks Grading Web sites "Toxin"=refers to toxic substances that are produced naturally "Toxicant"=substance that is produced by anthropogenic origin “Xenobiotic”= chemical foreign to the organism (Toxin or Toxicant) Toxic response is dependent on: Chemical and physical properties of the agent Exposure situation How the agent is metabolized Overall susceptibility of the biological system Molecular Toxicology Characterization of the targets and response of organisms to toxic agents to understand the mechanisms of toxicity in cells, tissues, and organisms 3...
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This note was uploaded on 03/09/2011 for the course NSI 20 taught by Professor Vulpe during the Spring '11 term at Berkeley.
- Spring '11