Lecture_05_ATP Homeostasis

Lecture_05_ATP Homeostasis - Lecture 5 ATP Homeostasis and...

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1 Lecture 5: ATP Homeostasis and Cell Metabolism G.A. Brooks: [email protected] 5101 VLSB (M,F 8:00 AM) Readings: Widmaier, Raff & Strang’s VS&L Chapters 2 & 3 IB 132 Just a few calories 2 Outline-ATP Homeostasis and Cell Metabolism ATP Homeostasis: Terminology and Atkinson (Adenylate Energy) Concept Energy Sources In Muscle and Other Cells Glycolysis and Glycogenolysis Lipid Metabolism β -Oxidation Amino Acid & Protein Metabolism Dietary Reference Intakes: DRIs, RDA, AI, UL Model of Energy Substrate partitioning “Crossover Concept” 3 Key Physiological Priorities Cell Membrane Potential: -90 to -55 mV depending on cell type Atkinson Energy Charge: 0.85 Mitochondrial Δψ : -0.22 v Blood [Glucose]: 100 mg/dl, or 5.5 mM Mean Arterial Pressure: 100 mmHg, or Torr Arterial pH: 7.38 Arterial Oxygen Partial Pressure: 100 Torr Plasma Osmolality: 282 mOsm Core Body Temperature: 37 o C 4 Key Physiological Priorities Cell Membrane Potential: -90 to -55 mV depending on cell type Atkinson Energy Charge: 0.85 Mitochondrial Δψ : -0.22 v, -220 mv Blood [Glucose]: 100 mg/dl, or 5.5 mM Mean Arterial Pressure: 100 mmHg, or Torr Arterial pH: 7.38 Arterial Oxygen Partial Pressure: 100 Torr Plasma Osmolality: 282 mOsm Core Body Temperature: 37 o C 5 Ways of Thinking What is sensed? What is regulated? What are the mechanisms? What are the controls? What are the limits? What happens when there are problems 6 6 ATP Fig. 2-24 Hydro/lysis
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7 Terminology ATP Homeostasis: Constant [ATP] Turnover: Rates of Production and Removal Production Rate = ADP Phosphorylation Synthesis- Appearance (Ra) Utilization Rate= Hydrolysis Use-Degradation-Disposal (Rd) 8 Energy Transductions in the Biosphere Photosynthesis: Cell Respiration: C 6 H 12 O 6 + 6O 2 6 CO 2 + 6 H 2 O + Energy Cell Work: ATP ADP + Pi + E Muscle Contraction, Gene Transcription, Protein Synthesis, Hormone Secretion, Ion Pumping, etc. 9 Photosynthesis Have you thanked the green plant today? 10 Cell Organization and Tissue Heterogeneity 11 Figure 3-2 Example of Tissue Cell Heterogeneity in Liver Figure 5-5 Transverse sections of skeletal muscle from a rodent, incubated for myofibril ar- ATPase at pH 10.3. Panel (a) is a section form the extensor digitorum longus (EDL) muscle, which is composed primarily of fibers that have high glycolytic capacity. Note the high proportion of dark- appearing fibers in the EDL muscle. In contrast, panel (b) is a section from the soleus (SOL) muscle, which is composed primarily of fibers low in glycolytic capacity (but high in oxidative type I fibers). Note the large number of light appearing fibers. Example of Tissue Cell Heterogeneity: Skeletal Muscle Fiber Types Figure 3-2 Alternate 1
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13 Example of Tissue Cell Heterogeneity: Skeletal Muscle Fiber Types Figure 3-2 Alternate 2 14 Cell Heterogeneity of Metabolism ATP and PCr (CP) in the cytosol Glycogen and glycolysis are in the cytosol Mitochondria contain enzymes of TCA Cycle, ETC, Beta-oxidation and GNG 15 ATP Use (Hydrolysis)
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This note was uploaded on 03/09/2011 for the course IB 132 taught by Professor Brooks during the Spring '08 term at Berkeley.

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Lecture_05_ATP Homeostasis - Lecture 5 ATP Homeostasis and...

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