Lecture_10_Muscle_Motors

Lecture_10_Muscle_Motors - Welcome to IB 132: Survey of...

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1 Welcome to IB 132: Survey of Human Physiology Lecture 09: Muscles as Motors Widmaier, Raff & Strang Chapter 9 Professor George A. Brooks Professor Daniela Kaufer Today’s Outline 1. Muscle Structure 2. Muscle Shortening Break 3. Neuro-muscular activation Why Study Muscle? 1. Muscle is a common effector in physiological control systems 2. Molecular motors are in common use. 3. Muscle is an endocrine organ as it releases myokines, much like fat (adipose) releases adipokines. Which Muscle to Study? 1. Skeletal muscle is the most common, the simplest and most studied. 2. We will study cardiac and smooth muscles in the regulation of blood pressure. 5 Alberto Tomba Speed and Power Ted Ligety- Gold Medal Men’s Combined, Turino 6 Muscles Provide Structure Function as Motors Metabolic Power and Metabolite Disposal Function as Springs Function as Part of a Servo Neuro-muscular Control System Permits posture, locomotion, reflex and voluntary activity. Permit Cell motility. Releases substances (myokines) that have autocrine, paracrine and endocrine effects.
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2 7 Skeletal Muscle Anatomy Whole muscle to: Fascicle to Fiber to Fibril to Sarcomere Actin & Myosin Filaments Sliding Filaments 8 Fig. 09.02 Fig. 9-2 Muscle Tissue Filament (Myofilament) Contractile Unit (Sarcomere) 9 Figure 09.01 Fascicle Fiber (Cell) Tissue Fig. 9-2A Bundles of (Fascicles) 10 Striated Means Striped A = Anisotropic (No Light passes through) A Band is the dark band I = Isotropic (Light passes through) I Band is the light band 11 Fig. 09.02 Fig. 9-2 Muscle Tissue A Band I Band 12 Fig. 09.02 Fig. 9-2 Muscle Tissue Myo- fibril Sarcomeres in parallel Myo- filaments
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3 13 Fig. 9-1 Skeletal Muscle Fibers Are Cells 14 Fig. 09.01a Myocytes Fig. 9-1 Light Micrograph Artist’s Rendition 15 Fig. 09.01b Cardiocyte Fig. 9-1 Cardiac and skeletal muscle are “striated” and are multinucleated Artist’s Rendition Light Micrograph 16 Fig. 09.01c Fig. 9-1 Artist’s Rendition Light Micrograph 17 18 Fig. 9-24r Skeletal Muscle Fiber Types Skeletal Muscle is Heterogeneous For several reasons
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4 19 Skeletal Muscle Fiber Types 20 Figure 18-16 In adult mammalian muscles, microscopic examination after transverse (cross) sectioning and hisological staining reveals three fiber types. Fibers are classified as either type I (slow) or type I (fast), depending on intensity of staining with alkaline myofibril ar ATPase. Note that type I and I fibers demonstrate an “acid reverse” when stained for myofibril ar ATPase at low pH (Ac-ATPase). With the oxidative marker succinic dehydrogenase (SDH), type I and type I a fibers stain dark, whereas type I b fibers stain stain lightly.
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This note was uploaded on 03/09/2011 for the course IB 132 taught by Professor Brooks during the Spring '08 term at Berkeley.

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Lecture_10_Muscle_Motors - Welcome to IB 132: Survey of...

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