Lecture_10r_Muscle_Motors

Lecture_10r_Muscle_M - Welcome to IB 132 Survey of Human Physiology Lecture 09 Muscles as Motors Widmaier Raff Strang Chapter 9 Todays Outline 1

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1 Welcome to IB 132: Survey of Human Physiology Lecture 09: Muscles as Motors Widmaier, Raff & Strang Chapter 9 Professor George A. Brooks Professor Daniela Kaufer Today’s Outline 1. Muscle Structure 2. Muscle Shortening Break 3. Neuro-muscular activation 3 Which is the Largest Organ System in the Body? a. Skin b. Adipose c. Cardiovascular d. Guts e. Musculoskeletal 4 Muscle Is Mostly? a. Actin b. Myosin c. Connective tissue d. H 2 0 e. Tropomyosin 5 Muscle Actions Are Controlled Mostly by: a. Spinal Reflexes b. Intrinsic mechanisms c. The Brain d. The Heart e. The weather 6 Striated and Cardiac Muscles Differ in that Cardiac Muscle Cells are not controlled by: a. Spinal Reflexes b. Intrinsic mechanisms c. The Brain d. Hormones e. Extracellular Ca ++
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2 Why Study Muscle? 1. Muscle is a common effector in physiological control systems 2. Molecular motors are in common use. 3. Muscle is an endocrine organ as it releases myokines, much like fat (adipose) releases adipokines. Which Muscle to Study? 1. Skeletal muscle is the most common, the simplest and most studied. 2. We will study cardiac and smooth muscles in the regulation of blood pressure. 9 Muscles as Motors Athlete or Politician? Athlete or Politician? 10 Alberto Tomba Speed and Power Ted Ligety- Gold Medal Men’s Combined, Turino 11 Muscles Provide Structure Function as Motors Metabolic Power and Metabolite Disposal Function as Springs Function as Part of a Servo Neuro-muscular Control System Permits posture, locomotion, reflex and voluntary activity. Permit Cell motility. Releases substances (myokines) that have autocrine, paracrine and endocrine effects. 12 Skeletal Muscle Anatomy Whole muscle to: Fascicle to Fiber to Fibril to Sarcomere Actin & Myosin Filaments Sliding Filaments
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3 13 Fig. 09.02 Fig. 9-2 Muscle Tissue Filament (Myofilament) Contractile Unit (Sarcomere) 14 Striated Means Striped A = Anisotropic (No Light passes through) A Band is the dark band I = Isotropic (Light passes through) I Band is the light band 15 Fig. 09.02 Fig. 9-2 Muscle Tissue A Band I Band 16 Fig. 09.01a Myocytes Fig. 9-1 Light Micrograph Artist’s Rendition 17 Fig. 09.01b Cardiocyte Fig. 9-1 Cardiac and skeletal muscle are “striated” and are multinucleated Artist’s Rendition Light Micrograph 18 Fig. 09.01c Fig. 9-1 Artist’s Rendition Light Micrograph
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4 19 20 Fig. 9-24r Skeletal Muscle Fiber Types Skeletal Muscle is Heterogeneous For several reasons 21 Skeletal Muscle Fiber Types 22 Figure 18-16 In adult mammalian muscles, microscopic examination after transverse (cross) sectioning and hisological staining reveals three fiber types. Fibers are classified as either type I (slow) or type I (fast), depending on intensity of staining with alkaline myofibril ar ATPase.
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This note was uploaded on 03/09/2011 for the course IB 132 taught by Professor Brooks during the Spring '08 term at University of California, Berkeley.

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Lecture_10r_Muscle_M - Welcome to IB 132 Survey of Human Physiology Lecture 09 Muscles as Motors Widmaier Raff Strang Chapter 9 Todays Outline 1

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