Lecture_12_Press___Circ - IB 132: Survey of Human...

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IB 132: Survey of Human Physiology Lecture 12: Control of Blood Pressure Professor George A. Brooks Professor Daniela Kaufer Outline:Control of Circulation Purposes of Circulation Control of Circulation Central Command (Feed Forward) Peripheral Sensing (Baroreflex, Pressor Reflex) (Feedforward and Feedback) Flow, Pressure Resistance Role of the Heart Role of the Blood Vessels Why this Slide? If not apparent, we will get to it later. Key Physiological Priorities Cell Membrane Potential: -90 to -55 mV depending on cell type Atkinson Energy Charge: 0.85 Mitochondrial Δψ : 0.22 v, -220 mv Blood [Glucose]: 100 mg/dl, or 5.5 mM Mean Arterial Pressure: 80-100 mmHg, or Torr Arterial pH: 7.38 Arterial Oxygen Partial Pressure: 100 Torr Plasma Osmolality: 282 mOsm Core Body Temperature: 37 o C Outline:Control of Circulation What is regulated? How is it sensed? What are the control mechanisms?
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Purposes of Circulation Maintain Blood Pressure Supply O 2 and Nutrients Remove ‘Wastes” Temperature Regulation Distribute Hormones, Growth factors and other ‘Humoral’ Signals Immuno-vigilance * What Circulates In Blood? Cells: Erythrocytes, Leukocytes, Plasma O 2 , CO 2 and H + Heat Hormones Metabolites Proteins Clotting Factors Electrolytes Growth Factors Immuno- Responsive Factors ‘Humors’ Figure 12-1 Proteins 7 %, 2 mM Albumin 4.2 g% Globulins 2.8 g% Fibrinogen 0.3 g% < 1% Solutes (mM) Na + 145 K + 4 Ca + 2.5 Mg ++ 1.5 Cl - 103 HCO 3 - 24 H 2 PO 4 -- 1.0 SO 2 -- 0.5 H + 0.0004 Glucose 5.5 AAs 2 Lipids 7.5 Hormones 10 -9 - 10 -6 Urea 5.7 Creatinine 0.1 Uric Acid 0.3 Bilirubin 0.01 H 2 O 93% Life Span 120 Days Blood Volume = 5-6 Liters and Mean Transit Time = 1 minute Figure 12-1m The major forms of “cells” in the blood. Among these, only the leukocytes are true cells with nuclei. Figure 12-70
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Stem cells in the bone marrow constitute an important precursor of many of the formed components in the blood. Figure 12-71 Appendix, 12th Edition RBC Life Span 120 Days Kidneys (mainly) and Liver Secrete Erythropoietin (EPO) Figure 12-68 Start Here Hypobaric Hypoxia Anemia* Low Hct Poor Diet Low Absorption Chelators Hook Worm Hemorrhage Diseases Sickle Cell Kidney
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This note was uploaded on 03/09/2011 for the course IB 132 taught by Professor Brooks during the Spring '08 term at University of California, Berkeley.

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Lecture_12_Press___Circ - IB 132: Survey of Human...

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