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Lecture_13_Q_Autor - IB 132 Human Physiology Lecture 13 Control of Cardiac Output and Regional Blood Flow Widmaier Raff& Strang Chapter 12

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Unformatted text preview: IB 132: Human Physiology Lecture 13: Control of Cardiac Output and Regional Blood Flow Widmaier, Raff & Strang Chapter 12 Professor George A. Brooks Professor Daniela Kaufer Today’s Outline • Frank-Starling Relationship • Fick Relationship • Control of Regional Blood Flow • Cardiac Pacing Myocardial Regulation • Extrinsic, e.g., influences of norepinephrine and epinephrine. • Intrinsic, e.g., the Frank- Starling or Length-Tension Relationship Autonomic Innervation of The Heart Sympathetic Innervation of The Heart and Circulating Catecholamines • Increase Heart Rate (Norepi) (+ Chronotropy) • Increase Strength of Contraction (Epi) (+ Inotropy) • Coronary Vasodilation • Peripheral Vasoconstriction Parasympathetic Innervation of The Heart • Decrease Heart Rate (ACH) (- Chronotropy) • Decrease Strength of Contraction (- Inotropy) • Mild Coronary Vasoconstriction • Peripheral Vasodilation Intrinsic Myocardial Regulation • Frank-Starling or Length-Tension Relationship Which Determines That The Strength of Contraction and Myocardial Length (EDV) • EDV is Related to Venous Return or “Preload.” Myocardial Function • Is Positively Affected by Venous Return or “Preload.” • Is Negatively Affected by Systolic Blood Pressure or “Afterload.” Operating Range for the Heart Normal Fig 9-21m (EDV) To increase the heart’s stroke volume: fill it more fully with blood. The increased stretch of the ventricle will align its actin and myosin in a more optimal pattern of overlap. Fig. 12-24 Ventricular Function “Starling” Curve “Positive Inotropy” Inotropy Increases the Ejection Fraction Fig. 12-25 Fig. 12-65 in HF Why for the failing heart is some fluid retention helpful, but more retention a major problem? What is the effect of CHD on Ejection Fraction? in HF Excessive Diastolic Filling If Weakened Myocardium Puts the Person on the Downslope of the Length- Tension Relationship in HF The “Fick Relationship” The Integration of Pulmonary Minute Ventilation, Cardiovascular Dynamics, and Oxygen Transport Use Adolph Fick (1829-1901) Würzburg The Fick Relationship of Oxygen Transport Use and Pulmonary Minute Ventilation VO 2 = Q (a-v)O 2 Q = VO 2 /(a-v)O 2 The Fick Relationship of Oxygen Transport Use VO 2 = Q (a-v)O 2 VO 2 = Flow ( O 2 Extraction) VO 2 = f V s (a-v)O 2 VO 2 = ( Heart Rate) (Stroke Volume) (O 2 Extraction) The Fick Relationship of Oxygen Transport Use The Fick Relationship of Oxygen Transport Use The Fick Relationship of Oxygen Transport Use VO 2 = Q (a-v)O...
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This note was uploaded on 03/09/2011 for the course IB 132 taught by Professor Brooks during the Spring '08 term at University of California, Berkeley.

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Lecture_13_Q_Autor - IB 132 Human Physiology Lecture 13 Control of Cardiac Output and Regional Blood Flow Widmaier Raff& Strang Chapter 12

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