lecture3_10 - 1/24/11 IB 132: Systems Human Physiology...

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1/24/11 1 IB 132: Systems Human Physiology Cellular homeostasis 1 READINGS : TODAY: CHAPTER 3 Sections A-B Thursday: CHAPTER 3 Sections C-D 2 Cell structure Membranes Organelles Central dogma: Genetic code Regulation of protein levels Today’s outline: 3 Learning Styles: VARK Questionnaire http://www.vark-learn.com/english/page.asp?p=questionnaire 4
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1/24/11 2 5 6 Molecular level… Reader’s digest version 7 Cells as the living units of the body Different cells are VERY different But are also very much THE SAME 8
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1/24/11 3 Adipocyte Neuron Erythrocyte Epithelial cell Different cells are very different phenotypocally and functionally 9 BUT. . All cells in an individual have the same genome (DNA content). All cells typically use the same structures, and chemical and biological reactions. How is the enormous diversity achieved? Lets start with what is the same. . 10 Inner life of a cell. . The movie http://multimedia.mcb.harvard.edu/media.html Narrated version: http://www.youtube.com/user/ArdalanBiology 11 Figure 3-4 12
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1/24/11 4 A Cell: Nucleus Cytoplasm Cytosol Organelles Extra-cellular fluid Intracellular fluid = cytosol+ organelle’s fluid 13 The extracellular and intracellular fluid INSIDE OUTSIDE A - A - A - A - K + K + K + K + Na + 12 K + 155 Cl - 4 Ca ++ 10 -5 Na + 145 K + 4 Cl - 120 Ca ++ 2 14 Maintains cells as distinct entity. Allows for separate internal environment. Regulates passage of substances in and out of cells (and organelles) Detect chemical messengers arriving at cell surface Link adjacent cells by various junctions Anchor cells to extracellular matrix ALL CELLS HAVE A PLASMA MEMBRANE 15 16 Solubility in Water • Molecules with ionic or polar covalent bonds have an electrical attraction to water molecules. • These molecules are able to dissolve in water and are called hydrophilic (water loving). • Molecules with nonpolar covalent bonds are not able to dissolve in water and are called hydrophobic (water fearing).
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1/24/11 5 17 Amphipathic Molecules Amphipathic molecules are a special class of molecules that have a polar or ionized region at one end and a nonpolar region at the opposite end. When mixed with water, amphipathic molecules form clusters, with
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This note was uploaded on 03/09/2011 for the course IB 132 taught by Professor Brooks during the Spring '08 term at University of California, Berkeley.

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lecture3_10 - 1/24/11 IB 132: Systems Human Physiology...

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