IB 117 _22 Cancer - paclitaxel (taxol), docetaxel...

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IB 117  Thomas Carlson Cancer remedies  Plant origin  Geographic  origin Mechanism of action /  therapeutic uses colchicum  colchicine Colchicum autumnale Europe Disorganizes spindle  mechanism at mitosis and  treats tumors and gout etoposide,  teniposide Podophyllum peltatum  P. hexandrum Eastern North  America, Himalayas Blocks G1 phase of mitosis  and tx testicular CA,  Hodgkin’s and non-Hodgkin’s  lymphomas podophyllum resin  from rhizome,  podophyllotoxin  Podophyllum peltatum  P. hexandrum Eastern North  America, Himalayas Binds microtubules causing  mitotic arrest in metaphase to  tx condylomata acuminata vincristine,  vinblastine Catharanthus roseus Madagascar Binds protein tubulin causing  mitotic arrest in metaphase to  tx acute childhood leukemia,  Hodgkin’s and non-Hodgkin’s  lymphomas
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Unformatted text preview: paclitaxel (taxol), docetaxel (taxotere) Taxus brevifolia NW North America antimicrotubule & antimitotic to tx metastatic ovarian and breast cancer European mistletoe Viscum album Europe Tx breast cancer and joint inflammation lycopene Solanum esculenta South America Antioxidant reduces risk of developing prostate CA phytochemicals in fruits and vegetables Reduces risk of developing cancer isoflavones, genistein Glycine max China Binds weakly to type II estrogen binding sites and outcompetes stronger estrogens resulting in a reduction in receptor stimulation and reduces risk for breast, uterine, and prostate cancers lignans in seed wall Linum usitatissimum Europe Reduces risk for breast cancer...
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IB 117 _22 Cancer - paclitaxel (taxol), docetaxel...

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