MCB+102+F10 lecture 02

MCB+102+F10 lecture 02 - Four Levels of Structure in...

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Four Levels of Structure in Proteins Primary Structure Secondary Structure Tertiary Structure Quaternary Structure
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C α H R COO - NH 3 + An L-amino acid Its D-enantiomer A common structure for α -amino acids (the C α atom is a chiral center)
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The naturally-occurring α -amino acids are the L-enantiomer
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R group is non-polar and aliphatic R group is aromatic R group is polar and uncharged R group is positively charged R group is negatively charged
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The R side chains differ in: (1) Size (volume/space occupied) (2) Shape (3) Polarity (hydrophobicity and hydrophilicity) (4) H-bonding capability (5) Ionizability (ability to pick up and lose H + ) (6) Charge ( + or -) (7) Chemical reactivity (esp. nucleophilicity)
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Alanine (Ala, A) Glycine (Gly, G) Not a chiral center
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Valine (Val,V) Leucine (Leu, L) Isoleucine (Ile,I) Methionine (Met, M) Another chiral center
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Proline (Pro, P) A secondary nitrogen atom So, proline is an imino acid
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Phenylalanine (Phe, F) Tyrosine (Tyr, Y) Tryptophan (Trp, W)
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MCB+102+F10 lecture 02 - Four Levels of Structure in...

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